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5 December 2013 11:26 am ,
Vol. 342 ,
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
Since arriving on the island of Guam in the 1940s, the brown tree snake ( Boiga irregularis ) has extirpated native...
An animal rights group known as the Nonhuman Rights Project filed lawsuits in three New York courts this week in an...
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
Thousands of scientists in the Russian Academy of Sciences (RAS) are about to lose their jobs as a result of the...
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
- 5 December 2013 11:26 am , Vol. 342 , #6163
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Commercial Gene Kingdom Splits Up
24 June 1997 8:00 pm
WASHINGTON--William Haseltine and J. Craig Venter, who graced the cover of Business Week as the "Gene Kings" in 1995, announced yesterday that they are going their separate ways. The breakup of a partnership that pioneered commercial DNA research is expected to unleash a flood of genetic data: Indeed, Venter's nonprofit DNA sequencing center, The Institute for Genomic Research (TIGR), today publicly released 40 million base pairs of DNA sequence data from 11 organisms, including portions of the genomes of the microbes responsible for tuberculosis, cholera, and syphilis, and chromosome 2 of the malaria parasite.
Craig Venter (right) and William Haseltine.
Haseltine's medical product development firm, Human Genome Sciences Inc. (HGS) in Rockville, Maryland, and TIGR, also in Rockville, effectively ended business relations on 20 June. TIGR will relinquish more than $38 million which it was due to receive from HGS over the next 5 years. HGS will release TIGR from patent requirements and publishing delays on future research. However, HGS retains rights to TIGR's earlier work.
The divorce was long in the making. HGS and TIGR came together in 1992 when the pharmaceutical company SmithKline Beecham invested $125 million in the two outfits to finance a hunt for human genes, the first big industrial leap into genomics. From the start, however, Venter chafed under commercial limits on data publication. HGS's attempts to delay the release of microbial sequencing data raised tensions to the boiling point. Last winter, HGS and TIGR began talking about a split-up (Science, 7 February, p. 778); formal negotiations began 2 months ago.
"This was an amicable decision," says Haseltine, one in "our mutual best interests." He says HGS was getting "diminishing returns" from its investment in TIGR since Venter had steered his outfit into sequencing organisms of little medical importance, and into human genome sequencing, also of limited value for a company like HGS that is interested in genes as drug targets (not untranslated DNA that makes up most of the genome). Venter, on the other hand, says that even at a cost of $38 million, TIGR's new freedom is "worth every penny."