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The Pyrenean ibex, an impressive mountain goat that lived in the central Pyrenees in Spain, went extinct in 2000. But a...
Tight budgets are forcing NASA to consider turning off one or more planetary science projects that have completed their...
Ebola is not a stranger to West Africa—an outbreak in the 1990s killed chimpanzees and sickened one researcher. But the...
In an as-yet-unpublished report, an international panel of geoscientists has concluded that a pair of deadly...
Tropical disease experts tried and failed before to eradicate yaws, a rare disfiguring disease of poor countries. Now,...
Since 2002, researchers have reported that agricultural communities in the hot and humid Pacific Coast of Central...
Balkan endemic kidney disease surfaced in the 1950s and for decades defied attempts to finger the cause. It occurred...
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Immune Cells Regrow a Rat's Spinal Cord
1 July 1998 7:00 pm
Scientists have got a rat's severed spinal cord to regrow after injecting it with certain immune cells. The results, reported in the July Nature Medicine, have sparked hope that the technique might help repair brain and spinal cord injuries in people as well.
In mammals, peripheral nerves can often repair themselves, but damage to the brain and spinal cord is mostly permanent. Many researchers have tried to coax these crucial tissues into healing themselves by treating them with growth factors or nerve helper cells that are thought to secrete restorative chemicals. These techniques have worked in rats, but have not been successfully transferred to humans.
Michal Schwartz and her colleagues at the Weizmann Institute of Science in Rehovot, Israel, decided to pursue what appeared to be a clue to regeneration: Neurons that can repair themselves attract immune cells called macrophages to the site of injury, while nonrepairing cells suffer silently. Following up on this observation, Schwartz's group severed the spinal cords of 22 rats, which paralyzed their hind legs, then injected macrophages into the area surrounding the injury. The researchers monitored the rats' recovery over the next 19 weeks by recording their ability to move their hind legs. Rats that didn't receive macrophages regained only the slightest twitch to their legs, while most macrophage-treated rats could move their legs in a sweeping motion and occasionally use them to support some of their weight. "It's a partial but very dramatic recovery," Schwartz says. Her team also found that new nerve fibers had grown across the injury gap.
"It's a very provocative finding," says Dalton Dietrich, a neuroscientist at the University of Miami School of Medicine in Florida. He notes that scientists used to think that macrophages at a wound site might help damaged tissue because they contribute to inflammation. "But this suggests that macrophages may be releasing substances that promote regeneration," he says. He cautions that many other potential treatments for spinal cord injuries have shown similar promise early on, but failed to pan out in further animal tests.