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17 April 2014 12:48 pm ,
Vol. 344 ,
Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
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Rat Race for Next Mammalian Genome
23 May 2000 6:00 pm
The rat will be the next target for publicly funded gene sequencing efforts in the United States, Francis Collins, director of the National Human Genome Research Institute (NHGRI) told his advisory council this week.
Until recently, no researcher would have considered taking on the burden of another mammal's genome while jammed sequencing centers worked through the human and mouse. But high-throughput labs at the Whitehead Institute in Boston, Baylor College of Medicine in Houston, Washington University in St. Louis, and the Joint Genome Institute in Walnut Creek, California, have added new machines and increased their capacity some 10-fold, says Robert Waterston, director of the Washington University center. Now their output, plus that of Britain's Sangre Center, is "enough to do a working draft of a mammalian genome in 4 to 5 months," Waterston told the council. As a result, the NHGRI-funded centers want to sequence the rat, mouse, and human genomes in parallel--if NHGRI and the National Heart, Lung, and Blood Institute can carve out funds from the still undecided 2001 budget.
Another mammalian sequence, says Raju Kucherlapati from Albert Einstein College of Medicine in New York City, would "really help with [interpreting] the human genome."