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5 December 2013 11:26 am ,
Vol. 342 ,
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
Snake venoms are remarkably complex mixtures that can stun or kill prey within minutes. But more and more researchers...
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
Since arriving on the island of Guam in the 1940s, the brown tree snake ( Boiga irregularis ) has extirpated native...
An animal rights group known as the Nonhuman Rights Project filed lawsuits in three New York courts this week in an...
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
- 5 December 2013 11:26 am , Vol. 342 , #6163
- About Us
Sticking With It No More
21 February 2001 7:00 pm
SAN FRANCISCO--For diabetics, life is a constant series of injections to control blood sugar with insulin. That may change, thanks to a new oral form of insulin that can be absorbed through the intestine. The pills have performed well in safety trials but have yet to be tested in a large clinical trial.
The balance of blood sugar and insulin, which cells need to absorb sugar, is a delicate operation. In a healthy person, the liver carefully regulates the flow of insulin and glucose into the bloodstream, keeping levels of both steady. Because their pancreases can't make insulin, diabetics must inject it straight into their bloodstream to keep blood sugar levels from rising too high. In addition to being painful and inconvenient, injections also bypass the liver, delivering insulin directly to muscle cells, which results in fluctuating blood insulin levels. Too much insulin can lead to hypoglycemia and other diabetes-related complications. Because the liver filters everything we eat, insulin taken orally more closely mimics natural insulin regulation. Unfortunately, insulin is easily digested in the stomach and does not penetrate the cells lining the intestinal wall. By chemically modifying the insulin molecule, scientists have apparently jumped this latter hurdle.
The new insulin includes a water-soluble polyethylene glycol chain, allowing the insulin to travel easily in the water-based environments of the intestine and bloodstream. A fat-soluble alkyl group helps the molecule cross the fat-based cell membranes in between. Exactly how it does this is still a matter of speculation, says Christopher Price, president of Nobex Corp. in Research Triangle Park, North Carolina, which developed the compound. Although the modification does not completely prevent digestion in the stomach, it does slow the process, so that some insulin can reach the intestinal wall.
At the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW) on 16 February, Price presented data from phase II clinical trials showing that the chemically modified insulin is safe and lowers glucose levels more rapidly than injected insulin does. And research in dogs with diabetes, Price says, has shown that the outfitted molecule controls glucose levels just as well as injected insulin does.
Other researchers advise caution, however. "Oral insulin has been just around the corner for years," says John Patton of Inhale Therapeutic Systems in San Carlos, California, which is developing an inhaled delivery system. "I spent many years studying the intestine. Getting [insulin] across that intestinal membrane and getting [it] absorbed into the body is very tricky business."