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17 April 2014 12:48 pm ,
Vol. 344 ,
Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
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Brain Cells Renewed in Rats
22 August 2002 (All day)
The adult brain is notoriously bad at healing itself. But a new study suggests it may just need a push to get started. Injections of growth factors yielded new brain cells in adult rats suffering from a stroke-like injury. The treatment restored some cognitive function, which raises the possibility that the brain's own cells could be stimulated to repair brain damage in humans.
The scientists, led by neurobiologist Masato Nakafuku of the University of Tokyo, simulated strokes by briefly shutting off arteries in the neck of rats. Then they infused a cocktail of growth factors directly into the animals' brains for several days. The growth factors didn't do anything to help the dying cells. But within a month, the rats had regained 40% of the neurons they'd lost--more than twice the regeneration that occurred without the growth factors. More importantly, the team reports in the 23 August issue of Cell, the treatment led to improved performance on a test of rat cognition--finding a submerged platform in a water maze.
The new cells grew from progenitor cells, stemlike cells that can divide to produce neurons. Many scientists believe that stimulating endogenous stem or progenitor cells to repair damage could be the ideal treatment for many diseases and injuries, because it circumvents problems--such as immune rejection or tumor creation--raised by injecting stem cells into a patient. But that's particularly difficult in the central nervous system, where little cell regeneration normally occurs.
So it's encouraging that the new study suggests stem cells are more widespread in the hippocampus than had been thought, says neuroscientist Mark Mattson of the National Institute on Aging's Gerontology Research Center in Baltimore, Maryland. "This is a very important study with implications for the treatment of patients," says Mattson. "These neurons are critical for learning and memory and are selectively damaged in stroke and Alzheimer's disease."