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5 December 2013 11:26 am ,
Vol. 342 ,
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
Since arriving on the island of Guam in the 1940s, the brown tree snake ( Boiga irregularis ) has extirpated native...
An animal rights group known as the Nonhuman Rights Project filed lawsuits in three New York courts this week in an...
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
Thousands of scientists in the Russian Academy of Sciences (RAS) are about to lose their jobs as a result of the...
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
- 5 December 2013 11:26 am , Vol. 342 , #6163
- About Us
Dude, Where's My Fear?
1 August 2002 (All day)
The same brain receptors that make marijuana smokers forget where they left their cars are also responsible for wiping out bad memories, new research suggests. The finding could lead to treatments for posttraumatic stress and other anxiety disorders.
The cannabinoid receptor CB1 gets its name from cannabis, the first substance known to activate it. More recently, native brain chemicals were shown to activate CB1 and thereby modulate memory, appetite, and pain. But scientists have only vague descriptions of the receptor's function. Neuroscientist Beat Lutz of the Max Planck Institute of Psychiatry in Munich, Germany, and colleagues thought one of CB1's jobs might be to get rid of certain memories once they outlive their usefulness--a phenomenon called memory extinction.
To test their theory, the researchers studied normal mice and mutant mice that lack CB1. They taught both kinds of mice to develop a so-called negative association when the researchers sounded a tone and simultaneously shocked the mice. The mice learn to recognize the tone and they freeze in fear when they hear it later, even without the shock. Normal mice start to lose this fear response after about 2 days. But mice lacking CB1 often freeze even 8 days after being shocked, the team reports in the 1 August issue of Nature. Giving normal mice a drug to suppress CB1 also blocks memory extinction. By analyzing brain tissue from the genetically normal mice, the researchers showed that sounding the tone without the shock activates two cannabinoid chemicals in the amygdala, a brain region responsible for fear, suggesting that cannabinoids help the mice unlearn the link between the tone and the shock.
"This is the first time anyone has implicated CB1 in extinction," says pharmacologist Aron Lichtman of Virginia Commonwealth University in Richmond. Lutz says the findings suggest that drugs that help native cannabinoids persist longer in the brain could be a good treatment for posttraumatic stress disorder, which involves the retention of unwanted memories.