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5 December 2013 11:26 am ,
Vol. 342 ,
An animal rights group known as the Nonhuman Rights Project filed lawsuits in three New York courts this week in an...
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
Thousands of scientists in the Russian Academy of Sciences (RAS) are about to lose their jobs as a result of the...
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
Snake venoms are remarkably complex mixtures that can stun or kill prey within minutes. But more and more researchers...
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
- 5 December 2013 11:26 am , Vol. 342 , #6163
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Potent Tumor Suppressor Found
18 June 2004 (All day)
Tumor suppressor genes are sentries standing guard against cancer: Knock them out, and tumors can suddenly surface. Now, researchers studying mice have found one of the most powerful tumor suppressor genes yet--animals lacking it have a startling 50% chance of developing cancer.
Dozens of tumor suppressor genes have been identified, but most are poorly understood. Many, though, share one thing in common: The genes can't handle damage to their DNA, and when mutated, they make cancer more likely. Razqallah Hakem, a cancer biologist at the University of Toronto in Ontario, and his colleagues normally study a tumor suppressor called BRCA1, variants of which put women at high risk of breast and ovarian cancer. But recently, his attention was drawn to a more mysterious gene that hadn't been tied to cancer: Mus81. Yeast lacking Mus81 were hypersensitive to radiation and other agents that harm DNA; in one yeast species, the gene appeared to be a critical player in cell division.
Hakem's team wondered if Mus81, with its sensitivity to DNA damage, might have a cancer link. To find out, the scientists bred mice that lacked either one or both copies of the gene. Only half the animals with one good copy of Mus81, and a quarter of those with no copies, remained healthy and survived a year. Tumors, especially lymphomas, ran rampant through every one of the sick mice, the team reports in the 18 June issue of Science. These mice were more likely to get tumors than mice lacking almost any other tumor suppressor, except the widely studied P53 gene, Hakem says.
The work also casts doubt on a widely held theory about the function of Mus81. Yeast studies had suggested that Mus81 was critical for a specific stage in cell division that's essential for chromosome recombination during reproduction. To the researchers' surprise, however, the animals missing one or both copies of Mus81 were fertile and produced normal egg and sperm cells. Apparently, Mus81 works differently in mice.
"Mus81 really does play a critical role" in suppressing tumors, says Stephen West, a biochemist at Cancer Research UK in London. It's especially striking, he says, that mice with only one defective copy of Mus81 get cancer. Hakem says that came as a surprise to him, too. Although the good copy of Mus81 can still make protein, Hakem says, that's apparently not enough to stave off cancer.