- News Home
17 April 2014 12:48 pm ,
Vol. 344 ,
Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
- About Us
Potent Tumor Suppressor Found
18 June 2004 (All day)
Tumor suppressor genes are sentries standing guard against cancer: Knock them out, and tumors can suddenly surface. Now, researchers studying mice have found one of the most powerful tumor suppressor genes yet--animals lacking it have a startling 50% chance of developing cancer.
Dozens of tumor suppressor genes have been identified, but most are poorly understood. Many, though, share one thing in common: The genes can't handle damage to their DNA, and when mutated, they make cancer more likely. Razqallah Hakem, a cancer biologist at the University of Toronto in Ontario, and his colleagues normally study a tumor suppressor called BRCA1, variants of which put women at high risk of breast and ovarian cancer. But recently, his attention was drawn to a more mysterious gene that hadn't been tied to cancer: Mus81. Yeast lacking Mus81 were hypersensitive to radiation and other agents that harm DNA; in one yeast species, the gene appeared to be a critical player in cell division.
Hakem's team wondered if Mus81, with its sensitivity to DNA damage, might have a cancer link. To find out, the scientists bred mice that lacked either one or both copies of the gene. Only half the animals with one good copy of Mus81, and a quarter of those with no copies, remained healthy and survived a year. Tumors, especially lymphomas, ran rampant through every one of the sick mice, the team reports in the 18 June issue of Science. These mice were more likely to get tumors than mice lacking almost any other tumor suppressor, except the widely studied P53 gene, Hakem says.
The work also casts doubt on a widely held theory about the function of Mus81. Yeast studies had suggested that Mus81 was critical for a specific stage in cell division that's essential for chromosome recombination during reproduction. To the researchers' surprise, however, the animals missing one or both copies of Mus81 were fertile and produced normal egg and sperm cells. Apparently, Mus81 works differently in mice.
"Mus81 really does play a critical role" in suppressing tumors, says Stephen West, a biochemist at Cancer Research UK in London. It's especially striking, he says, that mice with only one defective copy of Mus81 get cancer. Hakem says that came as a surprise to him, too. Although the good copy of Mus81 can still make protein, Hakem says, that's apparently not enough to stave off cancer.