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12 December 2013 1:00 pm ,
Vol. 342 ,
Evolutionary biologists have long studied how the Mexican tetra, a drab fish that lives in rivers and creeks but has...
Victorian astronomers spent countless hours laboriously charting the positions of stars in the sky. Such sky mapping,...
In an ambitious project to study 1000 years of sickness and health, researchers are excavating the graveyard of the now...
Stefan Behnisch has won awards for designing science labs and other buildings that are smart, sustainable, and...
The iconic 125-year-old Lick Observatory on Mount Hamilton near San Jose, California, is facing the threat of closure...
Recent results from the Curiosity Mars rover have helped scientists formulate a plan for the next phase of its mission...
A new, remarkably powerful drug that cripples the hepatitis C virus (HCV) came to market last week, but it sells for $...
In pretoothbrush populations, gumlines would often be marred by a thick, visible crust of calcium phosphate, food...
- 12 December 2013 1:00 pm , Vol. 342 , #6164
- About Us
It's Just That Part of the Brain
24 October 2005 (All day)
Bewildering mood swings and a hankering for chocolate: Those are the stereotypical signs of premenstrual syndrome. But what's really going on in women's heads during "that time of the month?" A new study shows that women's brains may be hard at work keeping their hormonally heightened emotions at bay--whether they're aware of it or not.
Long considered the seat of personality, a part of the frontal lobe of the brain called the orbitofrontal cortex (OFC) is associated with mood, decision-making, and motivation. Research suggests the region may inhibit certain behaviors and regulate emotions. Few studies, however, have looked directly at changes in brain function and processing across the menstrual cycle, says neurologist David Silbersweig of Weill Medical College at Cornell University in New York.
Silbersweig and his team used functional magnetic resonance imaging (fMRI) to study 12 subjects' neural response to 80 words. The team included negative words, such as rape, assault, and death; neutral words, such as bookcase and clarinet; and positive words, such as safe and gentle. To test how emotions altered behavior premenstrually compared to postmenstrually, the researchers also measured how quickly the women performed a simple motor task: When they saw a word in normal font, they pressed a button, but held off if it was italicized.
The researchers found that negative words hurt. When viewing negative words, premenstrual women showed increased activity in the medial OFC, which may inhibit behavioral and emotional responses, and lower activity in the lateral OFC, which may control sensory and evaluative functions. The premenstrual response to negative words was stronger than during the postmenstrual phase or to either neutral or positive words. Furthermore, during the premenstrual phase, the women performed the button-pressing task more slowly, suggesting the brain had to work a bit harder, the researchers report online this week in the Proceedings of the National Academy of Sciences.
Although the functions of the various OFC subregions aren't well understood, the region appears to be working harder in premenstrual women by simultaneously inhibiting negative behavior and suppressing negative sensory response, Silbersweig says.
"It's a great piece of work," says psychiatrist Scott Rauch of Massachusetts General Hospital in Boston. This study clearly establishes that the menstrual phase can have an impact on brain activity--and understanding that brain chemistry is a critical step to figuring out what might underlie observed differences in mood and anxiety disorders between the sexes, he adds.