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17 April 2014 12:48 pm ,
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Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
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Don't Fight the Fever
7 November 2006 (All day)
Nobody likes coming down with a fever, but feeling hot may do a body good. Researchers report online 5 November in Nature Immunology that a fever in mice revs up the immune response by helping white blood cells enter lymph nodes, where they join the battle against microbial invaders.
All mammals can develop fever when they're sick enough, and even cold-blooded animals with infections, such as fish and lizards, will seek warmth to raise their body temperatures. This suggests that fever somehow helps the body conquer the bugs. Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood into lymphoid tissue, where they learn to recognize and fight pathogens. Lymphocytes constantly circulate through blood vessels within lymph nodes and other lymphoid organs, but only some actually enter lymphoid tissue by crossing the walls of the vessels, known as high endothelial venules (HEVs).
Fever increases blood flow, which means more lymphocytes flow through lymphoid tissues. Evans' team had previously shown that fever also assists the passage of lymphocytes into lymphoid tissue, but they hadn't figured out what was happening on a molecular level.
So Evans and collaborators at Harvard University and in Germany gave healthy mice artificial fevers. The researchers put the mice in a warm chamber for 6 hours, which raised their core temperature 2.7 C degrees above normal, to 39.5 C (about 103 F). Then they injected the mice with lymphocytes labeled with a fluorescent dye. When viewed under a microscope, the warmed mice had more lymphocytes sticking to their HEV cells. As a result, twice as many lymphocytes as normal passed into the lymphoid tissue. The explanation: Heat caused the HEV cells to express on their surface higher levels of two so-called "homing" molecules, ICAM-1 and CCL21, which make lymphocytes tightly adhere to the HEV cells.
The new study "adds to our knowledge about why fever might be beneficial," says immunologist Andrew Luster of Harvard Medical School in Boston, who wrote an accompanying commentary. He says the findings could lead to new drugs for boosting the immune response against infections and cancer and for dampening inflammation in autoimmune diseases such as arthritis.
So what to do when fever strikes? That depends, says Evans. While fever might provide some benefit, it can be dangerous in children, and parents should follow a doctor's advice, she says.