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Expression of Concern About Centenarians Paper
11 November 2010 3:19 pm
Four months after a paper it published on the genetics of centenarians was criticized for possible flaws, Science published an Editorial Expression of Concern about the work, noting that the authors are redoing their data. The short note, by Editor-in-Chief Bruce Alberts, acknowledged that the study's authors "used a number of different genotyping platforms and neglected to perform data-quality control steps, which resulted in their reporting several false-positive single-nucleotide polymorphism (SNP) associations." SNPs are spots in the genome where a single DNA base can vary between individuals, and the paper sought to identify SNPs linked to a tendency to live a very long time.
"Science and the authors are taking these concerns seriously," Alberts wrote. Once it has the redone data in hand, likely by next month, the journal will re-evaluate the paper.