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17 April 2014 12:48 pm ,
Vol. 344 ,
Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
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ScienceShot: The Invisible Mouse
31 August 2011 2:31 pm
What goes on inside a mouse's brain? Even though researchers have developed ways to make neurons fluoresce, they have a hard time observing them in an intact animal. Enter a new chemical cocktail named Scale. Researchers serendipitously discovered that a mixture of urea, glycerol, and soap makes synthetic membranes transparent. When they tried the mixture on a developing mouse fetus, they found that it removed all of the pigment from the cells, rendering them completely transparent (right). The technique, described online this week in Nature Neuroscience, allows scientists to see fluorescent neurons buried several millimeters in the brain (inset). But no need to worry about invisible mice creeping into your kitchen; Scale is too strong to use on a living animal.
See more ScienceShots.