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5 December 2013 11:26 am ,
Vol. 342 ,
An animal rights group known as the Nonhuman Rights Project filed lawsuits in three New York courts this week in an...
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
Thousands of scientists in the Russian Academy of Sciences (RAS) are about to lose their jobs as a result of the...
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
Snake venoms are remarkably complex mixtures that can stun or kill prey within minutes. But more and more researchers...
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
- 5 December 2013 11:26 am , Vol. 342 , #6163
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Video: X-rays Paint Whole-Cell Portraits
17 February 2012 6:59 pm
VANCOUVER, CANADA—Imagine photographing every seed in a watermelon without cutting a single slice. Scientists can use x-rays to create similar internal portraits of whole cells, they reported here this morning at the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW). Like performing a cellular CT scan, researchers rapidly freeze a cell and snap its x-ray image once every 100 milliseconds. They can reconstruct an entire cell from 90-200 images in about 5 minutes. Using the differing light-absorption properties of organelles—the cell’s functional structures—the scientists can automatically identify and color-code this inner machinery, like in the T cell shown above (the nucleus is bright blue, mitochondria are pink, and lysosomes are yellow). Researchers can use the technique to count and calculate the volume of organelles, and even measure how much hemoglobin malarial parasites consume inside red blood cells. Peering inside a whole cell without the laborious slicing and staining of electron microscopy makes x-ray imaging quick, quantitative, and decidedly less mess.
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