See through bodies, faster

Yang et al., Cell (2014)

See through bodies, faster

Emily is a staff writer at Science.

Scientists don’t need superpowers to see through solid objects. For organs such as the brain, they have CLARITY, a technique for rendering tissue transparent by perfusing it with gel, then washing out the fatty molecules that make tissues opaque. Now, researchers have sped up the process, clearing whole rodent bodies within 2 weeks to create the transparent mice pictured above. Previously, it took that amount of time to clear a single mouse brain by soaking it in a bath of clearing chemicals. To accelerate the process, scientists delivered the gel and clearing agents directly into the bloodstreams of dead mice, clearing their kidneys, hearts, lungs, and intestines within days and their entire brains and bodies within weeks. Of what use is a see-through mouse corpse once completed? In a paper published online today in Cell, researchers say their new technique will allow them to map anatomical connections between the brain and body in unprecedented detail.

Posted in Biology