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24 April 2014 11:45 am ,
Vol. 344 ,
Major climate data sets have underestimated the rate of global warming in the last 15 years owing largely to poor data...
The tsetse fly is best known as the vector for the trypanosome parasites that cause sleeping sickness and a disease in...
The National Institutes of Health is revising its "two strikes" rule, which allowed researchers only one chance to...
By stabilizing the components of retromers, molecular complexes that act like recycling bins in cells, a recently...
Fossil fuels power modern society by generating heat, but much of that heat is wasted. Semiconductor devices called...
Researchers are gaining insights into what made Supertyphoon Haiyan so powerful and devastating through post-storm...
Millions around the world got a first-hand look at what it was like to be in Tacloban while it was pummeled by...
- 24 April 2014 11:45 am , Vol. 344 , #6182
- About Us
19 April 1999 6:30 pm
Today is the birthday of Ines Mandl, a U.S. biochemist who conducted pioneering research on enzymes and elastic tissue that led to advances in the understanding of pulmonary emphysema.
Mandl, who was born in 1917, investigated collagenases--a group of about 20 enzymes that can break down collagen into a soluble form--and was the first to isolate and purify one of the enzymes. As director of the obstetrics/gynecology laboratories of Delafield Hospital (affiliated with Columbia University), Mandl studied respiratory distress and emphysema in newborn babies and identified the role of elastin, an elastic tissue in the lungs. She showed that patients with emphysema had deterioration of elastin, which destroyed their lung tissue. Cigarette smoking, she found, also damaged elastin.
In 1972, Mandl founded the journal Connective Tissue Research.
Source: Benjamin F. Shearer and Barbara S. Shearer, Notable Women in the Physical Sciences: A biographical dictionary (Greenwood Press, 1997).