- News Home
17 April 2014 12:48 pm ,
Vol. 344 ,
Officials last week revealed that the U.S. contribution to ITER could cost $3.9 billion by 2034—roughly four times the...
An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now,...
Using the two high-quality genomes that exist for Neandertals and Denisovans, researchers find clues to gene activity...
A new report from the Intergovernmental Panel on Climate Change (IPCC) concludes that humanity has done little to slow...
Astronomers have discovered an Earth-sized planet in the habitable zone of a red dwarf—a star cooler than the sun—500...
Three years ago, Jennifer Francis of Rutgers University proposed that a warming Arctic was altering the behavior of the...
- 17 April 2014 12:48 pm , Vol. 344 , #6181
- About Us
19 April 1999 6:30 pm
Today is the birthday of Ines Mandl, a U.S. biochemist who conducted pioneering research on enzymes and elastic tissue that led to advances in the understanding of pulmonary emphysema.
Mandl, who was born in 1917, investigated collagenases--a group of about 20 enzymes that can break down collagen into a soluble form--and was the first to isolate and purify one of the enzymes. As director of the obstetrics/gynecology laboratories of Delafield Hospital (affiliated with Columbia University), Mandl studied respiratory distress and emphysema in newborn babies and identified the role of elastin, an elastic tissue in the lungs. She showed that patients with emphysema had deterioration of elastin, which destroyed their lung tissue. Cigarette smoking, she found, also damaged elastin.
In 1972, Mandl founded the journal Connective Tissue Research.
Source: Benjamin F. Shearer and Barbara S. Shearer, Notable Women in the Physical Sciences: A biographical dictionary (Greenwood Press, 1997).