- News Home
5 December 2013 11:26 am ,
Vol. 342 ,
Researchers have been hot on the trail of the elusive Denisovans, a type of ancient human known only by their DNA and...
Thousands of scientists in the Russian Academy of Sciences (RAS) are about to lose their jobs as a result of the...
Dyslexia, a learning disability that hinders reading, hasn't been associated with deficits in vision, hearing, or...
Exotic, elusive, and dangerous, snakes have fascinated humankind for millennia. They can be hard to find, yet their...
Researchers have sequenced and analyzed the first two snake genomes, which represent two evolutionary extremes. The...
Snake venoms are remarkably complex mixtures that can stun or kill prey within minutes. But more and more researchers...
At age 30, Dutch biologist Freek Vonk has built up a respectable career as a snake scientist. But in his home country,...
Since arriving on the island of Guam in the 1940s, the brown tree snake ( Boiga irregularis ) has extirpated native...
- 5 December 2013 11:26 am , Vol. 342 , #6163
- About Us
Deadly Viruses Have Been Part of Us for Millions of Years
29 July 2010 4:18 pm
Over the past few months, researchers have found that the viruses responsible for Ebola, Marburg hemorrhagic fever, and other deadly diseases have been hanging out in the genomes of certain mammals for tens of millions of years. It turns out that this was just the tip of the iceberg. Scientists have now discovered that these viruses have integrated themselves into the DNA of a wide range of animals, including humans, zebrafish, and other vertebrates. Although the researchers don't know whether the embedded viral sequences have a function, they suspect they are helpful to the animals—otherwise, they wouldn't have endured through millions of years of evolution.
The viruses in question belong to two families: Filoviruses, which include Ebola and Marburg, and Bornaviruses, which causes neurological diseases in certain animals, such as horses. All are RNA viruses, which means they can't easily convert their genetic material into DNA, a necessary step for integrating into an animal's genome. Yet they've done just that, and the new study suggests that they've been even more successful than scientists imagined.
Anna Skalka, a virologist at Fox Chase Cancer Center in Philadelphia, Pennsylvania, was on sabbatical at Princeton University when she heard about work showing that RNA viruses had integrated into insects and plants. Along with two colleagues, Vladimir Belyi and Arnold Levine, both at the Institute for Advanced Study in Princeton, New Jersey, she decided to see whether the same was true in vertebrates. Unlike the previous studies that focused on certain species or a particular RNA virus, Skalka went broad: She and her colleagues surveyed every vertebrate genome available, 48 in all, and looked for hints of 5666 RNA viral sequences from 38 known families and nine genera that were unclassified. It was "everything available that could be looked at," Skalka says.
The three "were floored" by the results, she says, as much for what they showed as what they didn't show. Nineteen of the species, including a squirrel, a small bat, a zebrafish, and a human had RNA viral sequences embedded in their DNA. But equally intriguing was how few different families of RNA viruses turned up: just Bornaviruses and Filoviruses. "It's a mystery as to why this should be," Skalka says. The integrations happened as long as 40 million years ago, the team reports today in PLOS Pathogens.
"It would be interesting to know what's special about these two [families] of viruses," says Jonathan Stoye, a virologist at the National Institute for Medical Research in London. He wonders exactly how the RNA viruses are infecting cells without harming them, allowing them to become a part of an animal's DNA. That said, it's still too early to know whether Bornaviruses and Filoviruses are really overrepresented, says Derek Taylor, an evolutionary biologist at the University at Buffalo in New York. That's because studies like this can't help but miss genetic sequences from viruses that have changed significantly over time, and the viruses may now look very different from how they did when they inserted themselves into a genome. "There may be some ancient ghosts in there," Skalka agrees, "but the surviving viruses have evolved so far that we can't recognize them anymore."
Skalka speculates that the sequences her team and others have found might protect the host from infection. Interestingly, horses are especially vulnerable to Bornaviruses, and no Bornavirus sequences showed up in these animals. In addition, bats had Ebola-like sequences, which the scientists speculate could help them transmit the disease without succumbing to it.