The Ebola treatment center in Nzérékoré, Guinea, one of the trial sites.

Xavier Anglaret and Dadoua Sissoko/INSERM

The Ebola treatment center in Nzérékoré, Guinea, one of the trial sites.

SEATTLE, WASHINGTON—When French scientists presented the results from an Ebola drug trial at a press conference on Monday, they did so with plenty of caveats, but their message was hopeful: The drug, favipiravir, appeared to lower mortality in people with low and medium-high levels of virus in their blood, the researchers told journalists at the Conference on Retroviruses and Opportunistic Infections (CROI) here.

But when study leader Denis Malvy of the University of Bordeaux in France presented more details of the results at CROI, many colleagues were underwhelmed. Several scientists criticized the evidence as well as the design of the trial, which is ongoing at four clinics in Guinea. “It doesn’t tell us anything,” said epidemiologist Scott Hammer of Columbia University, who chairs the meeting.

In his presentation, Malvy focused on a group of 40 patients who began the trial with lower viral loads than 29 others who clearly did not benefit from favipiravir. As he explained on Monday, only six of those 40 patients died—half of what was expected based on similar patients treated at the same clinics over the past 3 months. What’s more, after 4 days of starting treatment on favipiravir, an influenza drug, 51% of these patients had such low levels of the virus in their blood that the standard test could no longer detect it. “There was a signal that monotherapy with favipiravir may decrease viral load,” Malvy said.

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Earth scientists Jean Bergeron of the University of Sherbrooke; Lauren Garofalo of the University of California, Berkeley; and Lev Horodyskyj of Arizona State University participate in a climate negotiation game in late 2014.

Kerry Klein

Earth scientists Jean Bergeron of the University of Sherbrooke; Lauren Garofalo of the University of California, Berkeley; and Lev Horodyskyj of Arizona State University participate in a climate negotiation game in late 2014.

“Welcome, delegates,” the U. N. official boomed to the international negotiators gathered to find a way to prevent catastrophic global warming. The delegates whispered and scribbled on pie charts as she spoke. One popped open an orange cream soda.

“What is the planet,” the woman concluded, “that you will leave to our collective future?”

It’s a question those in the room contemplate daily. But on this day, they knew the burden of decision didn’t really rest on their shoulders—because neither the U.N. official nor the negotiation was real.

It was World Climate, a game that simulates international climate negotiations. The U.N. official was biogeochemist Juliette Rooney-Varga, director of the Climate Change Initiative at the University of Massachusetts, Lowell. And she addressed not diplomats, but earth scientists, gathered late last year in San Francisco for a meeting of the American Geophysical Union (AGU).

The game, created in 2010 by the nonprofit Climate Interactive and the Massachusetts Institute of Technology System Dynamics Group, is to U.N. climate negotiations what Model UN is to the real thing: a chance for outsiders to get a glimpse of what it takes to hammer out a consensus on a thorny international issue. And the players’ collective goal is straightforward: Commit enough resources to prevent dangerous global warming by the year 2100. The benchmark is to prevent Earth from warming more than 2°C above preindustrial levels, or about 1.2°C. higher than today—the same as the goal set by the United Nations’ climate agency.

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Mice have become the world’s most used mammal in research.

Armin Rodler/Flickr (CC BY-NC 2.0)

Mice have become the world’s most used mammal in research.

The number of animals used by the top federally funded U.S. biomedical research institutions has risen 73% over 15 years, a “dramatic increase” driven mostly by more mice, concludes an animal rights group. They say researchers are not doing enough to reduce their use of mice, which are exempt from some federal animal protection laws.

The National Institutes of Health (NIH), which collected the data, says the analysis by People for the Ethical Treatment of Animals (PETA) is “inappropriate.” The analysis was published online today in the Journal of Medical Ethics.

Although the Animal Welfare Act requires that the U.S. Department of Agriculture track research labs’ use of cats, dogs, and nonhuman primates, smaller vertebrates—including mice, rats, fish, and birds bred for research—are exempt. To get a sense of the trends, PETA filed Freedom of Information Act requests for data from inventories that NIH-funded institutions must submit to NIH every 4 years to receive an “assurance” allowing them to do animal research.

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H5N1

Cynthia Goldsmith/Wikimedia Commons

H5N1

Last fall, in a startling move, the U.S. government announced that a handful of U.S.-funded studies on risky pathogens were so dangerous that researchers should halt the work until experts could review them. After weeks of quiet, that review now appears to be moving forward. The National Institutes of Health (NIH) has chosen a private firm to conduct a formal risk assessment to help experts decide whether the halted studies, which generally focus on flu viruses, should ever be allowed to resume.

But two prominent scientists have written the National Science Advisory Board for Biosecurity (NSABB), a federal advisory board that is helping guide the analysis, to complain that it is being rushed through in secret and that the board lacks the needed range of expertise.

The controversy goes back to the fall of 2011, when two labs announced that they had modified the deadly H5n1 avian influenza virus to make it spread more readily in mammals. Many researchers worried about the risks of a pandemic if the new virus escaped the lab, and flu scientists doing so-called gain-of-function (GOF) experiments agreed to a 1-year pause in these studies. But the studies then restarted, despite ongoing concerns from many scientists that the risks were unacceptable.

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Climate change is just one controversial issue that provokes differing views on the relevant science. Here, demonstrators in Washington, D.C., in 2013.

Stephen Melkisethian/Flickr (CC BY-NC-ND 2.0)

Climate change is just one controversial issue that provokes differing views on the relevant science. Here, demonstrators in Washington, D.C., in 2013.

The bad news is that everybody does it. The good news is that social scientists are making progress in understanding why people ignore solid scientific evidence in deciding what they think about all manner of science-based issues—including how those topics should be taught in schools and addressed by policymakers.

The U.S. research community has long lamented how often the public disregards—or distorts—scientific findings. Many media pundits point the finger at partisan politics, although they offer contrasting explanations: Liberals often assert that Republicans are simply antiscience, whereas conservatives often insist that Democrats tout scientific findings to justify giving government a larger and more intrusive role.

A leading social science journal, The ANNALS of the American Academy of Political and Social Science, takes a deep dive into the debate by devoting its March issue (subscription required) to “The Politics of Science.” The issue, edited by political scientists Elizabeth Suhay of American University in Washington, D.C., and James Druckman of Northwestern University, includes some 15 articles that explore “the production, communication, and reception of scientific knowledge.” And nobody gets a free pass.

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Rajendra Pachauri in 2011.

Kris Krüg for PopTech/Flickr

Rajendra Pachauri in 2011.

The resignation of Rajendra Pachauri, the chair of the Intergovernmental Panel on Climate Change (IPCC), has focused new attention on the question of who will become the next head of the global body. Pachauri stepped down today amid allegations of sexual harassment by a female colleague, The Guardian reports. Pachauri, who had led the IPCC since 2002, had announced plans to step down this fall, The Daily Climate notes, after the group’s annual meeting in October. A new IPCC chair will be elected at that meeting by the panel’s 195 member nations, which nominate candidates.

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A mitochondrion.

Michael Taylor/Shutterstock

A mitochondrion.

The United Kingdom’s House of Lords has approved legislation to allow a new type of in vitro fertilization (IVF) that would replace faulty DNA, preventing certain types of genetic diseases. The vote follows the House of Commons approval of the measure on 3 February, making the United Kingdom the first country to explicitly allow the procedure, which would combine DNA from two biological parents and an egg donor.

The technique will be allowed under fairly tight regulation: Researchers who wish to offer the service to couples still must apply for and receive a license from the country’s Human Fertilisation and Embryology Authority.

The technique, called mitochondrial DNA replacement therapy, would allow women who have mutations in the DNA of their mitochondria, the organelles that provide chemical energy for cells, to have genetically related children who don’t carry the mutations. It is controversial, however, because it would modify the DNA of an embryo in a way that could be passed on to future generations.

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The study took place in an Ebola treatment center in Nzérékoré, Guinea.

Julien Rey/MSF

The study took place in an Ebola treatment center in Nzérékoré, Guinea.

SEATTLE, WASHINGTON—There’s a “slight hope” that it may help some people. That is the researchers’ sober assessment of an Ebola drug that made page one news earlier this month when it was touted as the first promising treatment for this deadly disease.

Those media reports relied on preliminary data on a trial of a new drug in Guinea that were leaked by a nongovernmental organization that was helping conduct the study, the researchers say. The New York Times broke the story on 4 February, and the same day, French President François Hollande issued a statement heralding the results as encouraging. “Healing is accelerated,” the statement read. Guinean officials announced they wanted to make the drug more widely available.

Yesterday was the first time the French team discussed their data publicly, speaking to the media at the Conference on Retroviruses and Opportunistic Infections (CROI) here.

In the opening press conference, the trial’s principal investigator, Denis Malvy of the University of Bordeaux, described the trial, called JIKI. Sixty-nine adults and adolescents took part in the study, from mid-December to mid-January. All participants received the drug, favipiravir, for up to 10 days. Their outcomes were compared with patients receiving standard care at the same clinics for the 3 months prior to the trial’s start. In all, 48% of the participants died, which is similar to the mortality rate in the historical control group. But when the researchers did a subset analysis of patients who entered the clinic with lower levels of Ebola virus in their blood, they found an increase in survival.

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Sivaranjan Uppala (center), a Ph.D. student from IISER Mohali, went on hunger strike last week to protest delays in research-stipend hikes for Indian postgraduate scholars.

Devendra Tiwari/Photos of Hike Research Fellowship

Sivaranjan Uppala (center), a Ph.D. student from IISER Mohali, went on hunger strike last week to protest delays in research-stipend hikes for Indian postgraduate scholars.

BANGALORE, INDIA—Indian postgraduate students have taken to the streets nationwide by the thousands over the past week to protest overdue hikes to government stipends. Unless demands are met soon, protest leaders promise to take more drastic action, such as a attempting a countrywide lab shutdown.

The protests began on 16 February, when Sivaranjan Uppala, a 29-year-old Ph.D. biomolecular imaging student at the Indian Institute of Science Education and Research, Mohali, began a hunger strike at Jantar Mantar, an ancient astronomical observatory near New Delhi. Uppala was subsequently joined by masses of students from premier research institutions across the country—including the Indian Institutes of Technology; the All India Institute of Medical Sciences, New Delhi; Jawaharlal Nehru University; and the Defence Research and Development Organisation—who marched, performed street plays, and boycotted labs. Then on 20 February, 200 students gathered outside India’s Ministry of Human Resource Development (MHRD) in New Delhi. Several were arrested before human resources minister Smriti Irani pledged to take action on the stipends. Uppala then called off his hunger strike.

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The Smithsonian Institution Building, also known as The Castle, which houses administrative offices.

Zach Frailey/Flickr (CC BY-NC-ND 2.0)

The Smithsonian Institution Building, also known as The Castle, which houses administrative offices.

The Smithsonian Institution has asked its independent Inspector General (IG) to investigate allegations that one of its researchers, aerospace engineer Willie Wei-Hock Soon, violated the conflict-of-interest policies of several journals by failing to disclose financial support from a large energy company in his technical papers.

“The Smithsonian is greatly concerned about the allegations surrounding Dr. Willie Soon’s failure to disclose funding sources for his climate change research,” the Smithsonian, which is based in Washington, D.C., said in a statement released late Sunday. “The Smithsonian is taking immediate action to address the issue: Acting Secretary Albert Horvath has asked the Smithsonian Inspector General to review the matter. Horvath will also lead a full review of Smithsonian ethics and disclosure policies governing the conduct of sponsored research to ensure they meet the highest standards.”

The statement also notes that the Smithsonian “does not support Dr. Soon’s conclusions on climate change.”

The moves come after two environmental advocacy groups released documents this past weekend that raised questions about whether Soon had fully disclosed his funding from the Southern Co., a major energy concern, in nine technical papers published in seven journals.

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Industry support for some climate scientists has prompted controversy.

Billy Wilson/Flickr

Industry support for some climate scientists has prompted controversy.

In 2008, a small technical journal received a paper on climate science that required some special attention. The sole author was Willie Wei-Hock Soon, an aerospace engineer at the Harvard-Smithsonian Center for Astrophysics (CfA) in Cambridge, Massachusetts. The study argued that changes in the sun’s radiation output played a major role in influencing shifts in Arctic air temperatures—a view at odds with mainstream climate science, which fingered atmospheric carbon dioxide as a bigger player.

Geographer Carol Harden, the editor of the journal, Physical Geography, was aware that Soon was a vociferous critic of the idea that humans were causing global warming and of proposals for the U.S. government to regulate greenhouse gas emissions. So “I knew that paper was hot potato,” she told ScienceInsider.

Still, Physical Geography published the 40-page study in 2009 after peer reviewers gave a green light, and Harden persuaded Soon to “adjust some of the wording … and take out some pretty toxic language” involving climate research.  At the time, however, she didn’t inquire about Soon’s funding sources or potential conflicts of interest. The journal’s publisher had “no specific disclosure form that I know of,” she says. “It was pretty much the honor system.”

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Nature to let potential authors try a double-blind date

Ale Ventura/Alto Press/Colourbox

The marquee research journal Nature and almost all of its sister publications this week announced that they will offer authors the option of participating in double-blind peer review, where both submitters and referees remain anonymous. The practice, which is common among humanities journals, has long been debated in the sciences, and several journals have recently taken the plunge. Some observers, however, remain skeptical of the value of double-blind systems and note that other journals are heading toward greater transparency.

Traditionally, scientific journals have adhered to a single-blind system, in which authors don’t know the identity of those reviewing their paper. But that system has led to concerns that it may contribute to bias against some authors, including women, minorities, and those from less prestigious institutions. In the last decade, publishers have tried to address those concerns by introducing various tweaks to the reviewing process.

Nature Publishing Group (NPG) began testing the double-blind system with Nature Climate Change and Nature Geoscience in May 2013, after an author survey indicated significant interest in the model. “We’re here to serve the needs of the research community, and it’s become increasingly clear that they want to have the option … to choose double-blind peer review,” said Véronique Kiermer, director of author and reviewer services at NPG.

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Rapid test for Ebola now available

Val Altounian/Science

The World Health Organization (WHO) has approved the first rapid diagnostic test for Ebola. The test needs no electricity, requires just a few drops of blood from a finger prick, and can return results in 15 minutes. That will be a huge help to health workers in remote areas.

Current PCR-based tests require a blood sample taken by needle, secure transport of the blood to a properly equipped laboratory with trained staff, and at least several hours to return results. Depending on how far away a suspected case is from a testing laboratory, it can take more than a day to receive test results.

The new test, produced by Corgenix, a company in Broomfield, Colorado, uses antibodies to identify a specific Ebola virus protein. The list price will be about $15 per test, says Robert Garry, a hemorrhagic disease expert at Tulane University in New Orleans, Louisiana, who helped develop the test. But discounts will be available, he says, for bulk purchases and suppliers for use in Africa. 

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Some NSF grants that lawmakers want to look at explore ways to make computers safe from attack.

Mike Strasser/USMA PAO/Flickr

Some NSF grants that lawmakers want to look at explore ways to make computers safe from attack.

Representative Lamar Smith (R–TX) has drawn a lot of attention for publicly chastising the National Science Foundation (NSF) for funding research on, say, China’s milk supply or ancient Icelandic textiles. But in criticizing government-funded research on seemingly obscure topics, or in far-away countries, Smith was simply joining a long line of politicians who over the years have claimed to be protecting U.S. taxpayers by questioning how research agencies spend money.

But last week the chair of the science committee in the U.S. House of Representatives may have crossed into uncharted territory with his new list of 13 “questionable” NSF grants. The letter, sent to NSF on 10 February, means that Smith has now asked NSF for detailed information on more than 60 grants. Most relate to climate, environmental, and social science, but the new request appears to reflect a much more ambiguous filter: For the first time, it contains several awards in the physical sciences, including one that has led to patented software to detect whether a computer has been taken over by malicious software and another that explores a long-standing mathematical puzzle.

Scientists are scratching their heads and asking themselves how anyone could consider such research to be an example of wasteful government spending. “I can’t figure out which bucket this fell into: silly, obvious, or low priority,” says one university administrator whose institution is a recipient of one of the grants. “Ah, well, we’ll soldier on.”

Detecting malware

As chair of the science committee in the U.S. House of Representatives, which oversees NSF and several other federal research agencies, Smith has spent the past 2 years demanding that NSF explain why it funded some research projects. He and NSF have reached a temporary agreement that allows his staff to review all relevant materials in a...Continue Reading »

Serhiy Kvit in 2014.

Ukraine Crisis Media Center

Serhiy Kvit in 2014.

In recent months, Serhiy Kvit, Ukraine’s education and science minister, has had the stressful task of overseeing the hurried relocation of 25 science-related institutions, including 11 universities, from separatist-controlled enclaves in eastern Ukraine’s Donetsk and Luhansk regions, or Donbas. The crisis, which began after Russia annexed the Crimean Peninsula last March, has overshadowed ambitious attempts that Kvit is helping orchestrate to reform Ukraine’s higher education and science. The latest move on this front is a draft science law promising sweeping changes, including a new competitive grants body similar to the U.S. National Science Foundation, that’s expected to be introduced into parliament in March or April.

A literary critic and journalist by training and former president of the National University of Kyiv-Mohyla Academy, Kvit, 49, has won high marks from reform-minded scientists since his appointment as minister in February 2014. On the sidelines of the AAAS meeting in San Jose, Kvit spoke with ScienceInsider about the strain of dealing with the crisis in Donbas and the challenges of reforming the National Academy of Sciences of Ukraine, which has been led since 1962 by 96-year-old metallurgist Boris Paton. This transcript was edited for brevity and clarity.

Q: The relocation of institutions from Donbas has been piecemeal: Many scientists and professors chose to remain in the separatist areas. Why?

A: We didn’t move whole universities, just motivated students and teachers. Some people thought that if they left their labs in Donbas, they would have no opportunity to continue to be researchers. For others, they did not want to leave their apartments or their relatives behind. Very few are on the side of the Russians and the terrorists.

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A new shot at reducing research red tape

Ashley Fisher/Flickr (CC BY-NC-SA 2.0)

No matter how much scientists complain about it, federal oversight of academic research isn’t going away. But could it be done better?

The chair of a new National Academies panel examining how the government keeps tabs on its $40-billion-a-year investment wants that oversight “to be sensible enough so that investigators have more time to do research.” That’s a reference to an often-cited 2005 survey in which faculty say that “administrative tasks”—such as complying with agency reporting requirements—take up 42% of the time they devote to federally supported research projects.

Speaking yesterday during a break at the panel’s first meeting in Washington, D.C., Larry Faulkner, president emeritus of the University of Texas (UT), Austin, told ScienceInsider that “it would be a mistake to think that the only purpose of this study is to lighten the regulatory burden on universities. Regulation is required, it’s justified, and it’s needed. What we’re trying to do is guide both government and higher education to find more efficient ways to address those needs.”

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Open records laws becoming vehicle for harassing academic researchers, report warns

Jared Rodriguez/Truthout/Flickr

The electronic age of communication is making it easier for activists, companies, and lobbying groups to use state open records laws—designed to promote transparency—to harass academic researchers they disagree with, a scientific integrity group warns in a new report. The findings underscore the need for states to revisit how the laws are implemented and for universities to clarify how they balance privacy, transparency, and academic freedom in responding to requests for e-mails, letters, and other documents, the report argues.

“[I]ndividuals and well-heeled special interests across the political spectrum are increasingly using broad open records requests to attack and harass scientists and other researchers and shut down conversation at public universities,” warns the report from the Union of Concerned Scientists (UCS), which was unveiled today at a session of the annual meeting of AAAS (which publishes Science) in San Jose, California. It documents numerous examples of university researchers becoming engaged in often lengthy and complex battles with outside groups requesting internal records.

But that doesn’t have to happen, concludes the report, authored by Michael Halpern, a program manager for strategy and innovation at UCS’s Center for Science and Democracy in Washington, D.C. “If lawmakers, universities, and researchers develop a shared understanding of what they should disclose and a system for proactively doing so, they can avoid costly and time-consuming lawsuits and other battles,” it states. “And that, in turn, will allow researchers to get back to what they are supposed to be doing: learning more about our world.”

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A graphic message sent into space by the Arecibo radio telescope in the 1970s.

Arne Nordmann/Creative Commons

A graphic message sent into space by the Arecibo radio telescope in the 1970s.

SAN JOSE, CALIFORNIA—Is it time to send deliberate messages to the stars, in the hopes of reaching alien civilizations? Advocates in the Search for Extraterrestrial Intelligence (SETI) say that moment is long overdue. But other researchers want to take a more cautious approach and seek an international consensus before outing Earth to the rest of the universe. Scientists in both camps faced off today at a debate held at a meeting of AAAS (which publishes Science) here.

Douglas Vakoch, the director of interstellar message composition at the SETI Institute in Mountain View, California, doesn’t dismiss the need to consider ethical or political issues, but says that it will be tough to achieve a consensus. “It’s ‘either-or’ thinking,” he says. “Either we have international discussion, or we transmit. We should be doing both.” But David Brin, an astrophysicist and science fiction author here, says that Earth’s relative radio quietude should not be changed so radically, so quickly. “If you’re going to transform one of the major characteristics … of our planet, we’ve learned that small groups shouldn’t do that peremptorily.”

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GM food opponents, like these in Los Angeles, are adopting new strategies that put academics on the spot.

Lucy Nicholson/Reuters/Corbis

GM food opponents, like these in Los Angeles, are adopting new strategies that put academics on the spot.

The fierce public relations war over genetically modified (GM) food has a new front. A nonprofit group opposed to GM products filed a flurry of freedom of information requests late last month with at least four U.S. universities, asking administrators to turn over any correspondence between a dozen academic researchers and a handful of agricultural companies, trade groups, and PR firms. The scientists—many of whom have publicly supported agricultural biotechnologies—are debating how best to respond, and at least one university has already rejected the request.

“It seems like a fishing expedition to me,” says geneticist Alison Van Eenennaam of the University of California (UC), Davis, one of six UC researchers targeted by the requests. “I am very worried [the correspondence] is going to be used to sully the reputations of scientists.” The tactic is familiar in another controversial area, climate science, where researchers have faced an avalanche of document requests from climate change skeptics.

The group, U.S. Right to Know (USRTK) of Oakland, California, says it has no vendetta. It has targeted only researchers who have written articles posted on GMO Answers, a website backed by food and biotechnology firms, and work in states with laws that require public institutions to share many internal documents on request, says Executive Director Gary Ruskin. USRTK is interested in documenting links between universities and business, he says, and is “especially looking to learn how these faculty members have been appropriated into the PR machine for the chemical-agro industry.”

(After this article was published, ScienceInsider learned that a number of the scientists receiving freedom of information requests from USRTK have no involvement with GMO Answers. In an e-mail, Ruskin writes that he was incorrect on this point and apologized for the error. He says he requested documents from the scientists with no...Continue Reading »

A new report tries to simplify diagnosis of what were called ME/CFS patients and says that cardiopulmonary exercise tests are not necessary.

Zuma Press Inc./Alamy

A new report tries to simplify diagnosis of what were called ME/CFS patients and says that cardiopulmonary exercise tests are not necessary.

A committee convened by the Institute of Medicine (IOM) has proposed a new name for a condition known variously as chronic fatigue syndrome or myalgic encephalomyelitis. The unwieldy new moniker: systemic exertion intolerance disease, or SEID. In a report released today, the committee also suggests a new set of diagnostic criteria for SEID.

After reviewing more than 9000 scientific studies, hearing testimony from experts, and soliciting input from the public, the committee concluded that “the name ‘chronic fatigue syndrome’ has done a disservice to many patients,” calling it  “stigmatizing and trivializing.” Myalgic encephalomyelitis (ME), they noted, “does not accurately describe the major features of the disease.”

At least 20 sets of diagnostic criteria exist, the committee noted, which has confused patients, clinicians, and their families, as well as researchers studying the disease. The proposed diagnostic criteria are more focused on “the central symptoms” such as a reduced or impaired ability to work and study, malaise after exertion, and “unrefreshing” sleep.  The report, “Beyond Myalgic Encephalitis/Chronic Fatigue Syndrome: Redefining an Illness,” runs 235 pages.

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Damage from the 2009 L’Aquila earthquake.

DARKROOM DAZE/FLICKR (CC BY-NC-SA 2.0)

Six scientists convicted of manslaughter in 2012 for advice they gave ahead of the deadly L'Aquila earthquake were victims of "uncertain and fallacious" reasoning. So say the three judges who acquitted the experts and reduced the sentence of a seventh defendant last November. In a 389-page document deposited in court on Friday and since released to the public, the trio of magistrates attack the convictions on multiple grounds and state that no blame can be laid on the scientists for the risk analysis they carried out (find links to document in first sentence here). Other scientists, however, accuse the judges of failing to understand modern seismology.

The six scientists—three seismologists, a volcanologist, and two seismic engineers—together with a public official were put on trial in 2011 for advice they gave at a meeting of an official government advisory committee known as the Major Risks Commission held on 31 March 2009. The judge in that trial, Marco Billi, concluded that the experts' advice was unjustifiably reassuring and led some of the 309 victims of the earthquake, which struck L'Aquila in the early hours of 6 April 2009, to underestimate the threat posed by the ongoing "swarm" of tremors and so remain indoors on that fateful night rather than seek shelter outdoors. Describing the experts' risk analysis as "superficial, approximate and generic," Billi sentenced each of them to 6 years in jail.

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RIKEN President Ryoji Noyori, at the announcement last year of plans to restructure the center at the heart of the STAP stem cell controversy.

Dennis Normile/Science

RIKEN President Ryoji Noyori, at the announcement last year of plans to restructure the center at the heart of the STAP stem cell controversy.

TOKYO—RIKEN, the network of nationally supported Japanese labs, today handed out disciplinary measures for those involved in the STAP stem cell scandal who remain under its authority.

The actions result from nearly a year's worth of investigations centered on an article and a letter published online in Nature on 29 January 2014 that described a new and extremely simple way of generating stem cells called stimulus-triggered acquisition of pluripotency, or STAP. Nature retracted the papers last July. Even before the retraction, a RIKEN panel found lead author Haruko Obokata guilty of research misconduct for fabricated and falsified images. Investigators also concluded that several of Obokata's supervisors bore a heavy responsibility for the mess because of their lax oversight. 

Obokata resigned in December after failing to reproduce her research results. Also in December, a RIKEN investigative team concluded that STAP cells never existed and that indications of pluripotency reported in experiments likely resulted from contamination of cell lines.

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Shoukhrat Mitalipov (left), of Oregon Health & Science University and MitoGenome Therapeutics, shakes hands with Woo Suk Hwang of Sooam Biotech Research Foundation in Seoul (second from right) and two others to seal a cooperative research agreement.

Boyalife

Shoukhrat Mitalipov (left), of Oregon Health & Science University and MitoGenome Therapeutics, shakes hands with Woo Suk Hwang of Sooam Biotech Research Foundation in Seoul (second from right) and two others to seal a cooperative research agreement.

The scientist who once fraudulently claimed to have created embryonic stem cells matched to human patients and the one who really did it plan to conduct joint research, a Korean newspaper reported this morning. A Chinese regenerative medicine company will provide financial support, according to the account.

The two scientists would seem an odd match. In 2006, Woo Suk Hwang had to retract two papers published in Science in which his team claimed it had used the technique employed in cloning Dolly the sheep to create human embryonic stem cells matched to specific people who had various diseases.    After investigators determined all the claims were bogus, Hwang was fired from Seoul National University and later convicted of embezzling research funds and bioethics violations. He escaped jail time with a suspended sentence. Since his downfall, Hwang has quietly continued his cloning work on animals, particularly pet dogs, at Seoul-based Sooam Biotech Research Foundation, a private institute friends established specifically for him.

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A little bias in peer review scores can translate into big money, simulation finds

sanickels/Flickr

Late last month, many scientists submitted their first grant proposals of the year to the National Institutes of Health (NIH), the largest U.S. funder of biomedical research. Each will be graded by a panel of external reviewers—scientists who volunteer to rate the merit of the ideas presented by their peers. The scores peer reviewers award will play a big role in deciding which proposals NIH funds, and the process is extremely competitive: In 2014, the agency funded just 18.8% of the more than 27,000 proposals for a bread-and-butter R01 grant.

In recent years, however, some observers have been questioning whether merit alone determines the outcome of such peer reviews, which many agencies around the world use to award research grants. Some studies have found that certain geographic or demographic groups, such as minorities or researchers from certain states, can fare unusually poorly in funding competitions, raising concerns that bias—conscious or unconscious—is skewing scores. Other experiments have raised questions about the role of randomness and subjectivity in scoring, showing that two groups of reviewers can give the same proposals very different scores, leading to different funding outcomes.

Now, a new computer simulation explores just how sensitive the process might be to bias and randomness. Its answer: very. Small biases can have big consequences, concludes Eugene Day, a health care systems engineer at the Children's Hospital of Philadelphia, in Research Policy. He found that bias that skews scores by just 3% can result in noticeable disparities in funding rates.

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U.S. should fund climate engineering research, report concludes

NASA

A panel of the National Research Council (NRC) is calling for federal funding of research into two controversial areas of climate science: removing carbon dioxide directly from the atmosphere and albedo modification (AM), or shading the planet from the sun by tinkering with the sky. The recommendations, found in a two-volume report released today, move the so-called geoengineering techniques, long verboten among scientists, one step closer to the mainstream.

“The two main options for responding to the risks of climate change involve mitigationreducing and eventually eliminating human-caused emission of CO2 and other greenhouse gasesand adaptation,” the authors write. “It may be prudent to examine additional options, namely [carbon dioxide removal] and albedo modification.”

Strategies to remove carbon dioxide from the atmosphere and store it are becoming possible but are “limited by cost and technological immaturity,” concludes the 16-member panel, which was led by geoscientist Marcia McNutt, the former head of the U.S. Geological Survey and now editor-in-chief of Science (publisher of ScienceInsider). In contrast, “albedo-modification technologies, which aim to increase the ability of Earth or clouds to reflect incoming sunlight, pose considerable risks and should not be deployed at this time,” the panel says. But the federal government should fund studies into both, it adds.

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