• A new drug war

    As a growing wave of designer drugs hits the streets, researchers try to forecast which will prove most popular—and dangerous.

  • Alarm over synthetic cannabinoids

    Marketed as mimicking the effects of marijuana, synthetic cannabinoids are far from benign.

  • Using science to fight animal research

    Animal rights activist Justin Goodman is using science's own tools to combat animal research.

  • Probing the proton

    A newly upgraded accelerator explores the seething maelstrom at the heart of matter.

  • The cancer stem cell gamble

    Researchers are betting that a round of clinical trials will prove a controversial cancer theory and deliver new treatments.

  • On the trail of the Ebola virus

    One team's quest to find a potential Ebola case in Liberia reveals how difficult it will be to end the epidemic.

  • Salvaging science

    Underwater archaeologist Charles Beeker works to preserve famous wrecks as museums.

  • A science exodus from Ukraine's rebellious East

    Thousands of scientists—along with entire universities—have fled war-torn eastern Ukraine. Others have staked their futures on the breakaway republics.

  • Ukraine mourns a lost science jewel

    Russia's annexation of Crimea was a big blow to Ukrainian science.

  • Inflammation's stop signals

    Inflammation doesn't just peter out. The body actively shuts it down, using signals that researchers hope to transform into therapies.

  • Comet Breakthrough of the Year + People's choice

    Rosetta's short-lived lander grabbed the headlines, but the ongoing orbital mission is the real news for science. And this year, Science decided to give its readers a say in picking their own top breakthroughs of 2014.

  • Runners-up

    In addition to its Breakthrough of the Year, Science named nine runners-up as significant scientific achievements of 2014.

  • Scorecard for 2014

    Every year, the Breakthrough staff picks scientific developments likely to make news in the coming months.

  • Areas to watch in 2015

    Science is a moving target. In addition to looking back on achievements of the previous year, the Breakthrough staff also hazards a few informed guesses about developments likely to make news in months to come.

  • Breakdown + Breakdown runners-up

    Slow international response and missed opportunities to contain the outbreak make this year's Ebola epidemic Science's breakdown of the year. Also, Breakthrough staff chose a few of this year's notable flaps, stumbles, and reverses as runners-up.

  • Dino-killer Theory: Back from the Dead

    The once-moribund idea that volcanism helped kill off the dinosaurs gains new credibility.

  • Is DNA a Live Wire?

    Do cells use electricity to repair DNA? Jacqueline Barton aims to find out.

  • The mystery of the dead galaxies

    Astronomers thought they knew why all galaxies eventually redden and die. They were wrong.

  • A dose of reality

    Does any treatment work against Ebola? Researchers may soon find out, if they can overcome daunting ethical and practical challenges.

  • Saving lives without new drugs

    A push for improving basic care of Ebola patients could save many lives without experimental treatments.

  • The river masters

    Hippos are the nutrient kingpins of Africa's waterways.

  • A glimpse of cosmic dawn

    Astronomers are attempting to look back to when the first stars and galaxies lit up and changed the universe forever.

  • Rare earth

    Soil scientists are tracking down rare and endangered soils in a quest to document—and preserve—“pedodiversity.”

  • Stepping on the gas

    What would it take to put you behind the wheel of a methane-powered vehicle? Researchers are determined to find out.

  • Show me the money

    A bitter dispute lays bare questionable practices in China's foreign-talent programs.