• Cause of death

    No one knows why many people die in developing countries. A new technique, the minimally invasive autopsy, could change that—and transform global health.

  • How wolves have—and haven’t—transformed Yellowstone

    Yellowstone Park is a real-world laboratory of predator-prey relations.

  • The quest to turn eye transplants from science fiction into reality

    Eye transplants are science fiction. A team of researchers wants to change that.

  • The synthesis machine

    An automatic device that makes small organic molecules could revolutionize drug discovery.

  • Cleanup crew

    Unorthodox immune proteins called natural antibodies target pathogens and remove cellular and molecular waste.

  • What's in a name?

    Naming research animals may improve their well-being—or bias experiments.

  • Line of attack

    Christopher Korch is adding up the costs of contaminated cell lines.

  • Is the melting Arctic causing frigid winters?

    Scientists struggle to piece together an atmospheric puzzle.

  • The Siberian snow connection

    Melting sea ice may have grabbed headlines, but one researcher suggests another link between the changing Arctic and midlatitude weather.

  • Who are the Tibetans?

    China and some scientists say they are Chinese. But others see a richer picture.

  • Half-billion-dollar effort to turn scientists into teachers faces questions

    NSF has spent $500 million to train thousands of science and math teachers. But what has that meant for kids?

  • A new drug war

    As a growing wave of designer drugs hits the streets, researchers try to forecast which will prove most popular—and dangerous.

  • Alarm over synthetic cannabinoids

    Marketed as mimicking the effects of marijuana, synthetic cannabinoids are far from benign.

  • Using science to fight animal research

    Animal rights activist Justin Goodman is using science's own tools to combat animal research.

  • Probing the proton

    A newly upgraded accelerator explores the seething maelstrom at the heart of matter.

  • The cancer stem cell gamble

    Researchers are betting that a round of clinical trials will prove a controversial cancer theory and deliver new treatments.

  • On the trail of the Ebola virus

    One team's quest to find a potential Ebola case in Liberia reveals how difficult it will be to end the epidemic.

  • Salvaging science

    Underwater archaeologist Charles Beeker works to preserve famous wrecks as museums.

  • A science exodus from Ukraine's rebellious East

    Thousands of scientists—along with entire universities—have fled war-torn eastern Ukraine. Others have staked their futures on the breakaway republics.

  • Ukraine mourns a lost science jewel

    Russia's annexation of Crimea was a big blow to Ukrainian science.

  • Inflammation's stop signals

    Inflammation doesn't just peter out. The body actively shuts it down, using signals that researchers hope to transform into therapies.

  • Breakdown + Breakdown runners-up

    Slow international response and missed opportunities to contain the outbreak make this year's Ebola epidemic Science's breakdown of the year. Also, Breakthrough staff chose a few of this year's notable flaps, stumbles, and reverses as runners-up.

  • Comet Breakthrough of the Year + People's choice

    Rosetta's short-lived lander grabbed the headlines, but the ongoing orbital mission is the real news for science. And this year, Science decided to give its readers a say in picking their own top breakthroughs of 2014.

  • Runners-up

    In addition to its Breakthrough of the Year, Science named nine runners-up as significant scientific achievements of 2014.

  • Scorecard for 2014

    Every year, the Breakthrough staff picks scientific developments likely to make news in the coming months.